Grignard reaction and products. VI. The reaction of grignard reagents with 2-phenoxy- and 2-benzyloxy-cyclohexanone oximes.

The Solvent Effects on Grignard Reaction

This research focuses on the effects of water in a solvent on a synthetic process of a Grignard reagent which is common in organic synthesis and triggered an accident in Japan. For the measurement, a hermetically sealed apparatus was prepared to fit a small-scaled reaction calorimeter. The experimental results revealed that the induction period appeared as the water content in the solvent incre...

Di-Grignard reagents and metallacycles

Aliphatic ,w-dibromides can be converted to the corresponding c,w-di—Grignard reagents; for those members carrying less than four carbon atoms between the functions, special procedures are required. The synthesis, structure and applications of the di-Grignard reagents are discussed; particular emphasis is placed on the structures of the corresponding cyclic dialkylmagnesiums, and on the use of ...

Reaction Between Grignard Reagents and Heterocyclic N-oxides Synthesis of Substituted Pyridines, Piperidines and Piperazines

Single electron transfer-induced cross-coupling reaction of alkenyl halides with aryl Grignard reagents.

Alkenyl halides were found to undergo coupling with aryl Grignard reagents to give the corresponding styrene derivatives in a stereo-retained manner. The cross-coupling reaction is considered to proceed through a single electron transfer mechanism.

An unusual reaction of α-alkoxyphosphonium salts with Grignard reagents under an O2 atmosphere.

An unusual and novel reaction of α-alkoxyphosphonium salts, generated from O,O-acetals and Ph(3)P, with Grignard reagents under an O(2) atmosphere afforded alcohols in moderate to high yields. It was clarified by isotopic labelling experiments that the reaction proceeded via a novel radical pathway.